I am a research associate since 2013 at the Institut National de la Recherche Agronomique (INRA) in the team Biology & Bioinformatics of Signalling Systems (BIOS). This team is an interdisciplinary team composed of biologists, informaticians and mathematicians. The main research area of the BIOS team is the study of the dynamics of cellular signalling networks, using a system biology approach. We perform biological experiments at different scales (molecular, cellular, physiological) as well as informatical and mathematical modelling. We work on hormonal receptors of type GPCR (G protein-coupled receptors), which is a large protein family of receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. The team focuses in particular on the reproduction signalling pathways, and to receptors of gonadotropins. We aim at developing new pharmacological approches to control the activity of receptors linked to the reproduction system, in both farm animal and humans. The modelisation part consists in building tools to simulate and predict the behavior of signalling networks in various conditions.
My works deals with deterministic and stochastic models of biological problem, particulary from cellular and molecular biology (including signalling systems, reaction networks, gene expression model, cell differentiation model and protein aggregation model). I'm interested in hybrid modelling, and study stochastic processes, limit theorem, asymptotic properties. I'm currently investigated properties of (large) biological reaction networks, and the important questions of robustness and identifiability of parameters in such networks.
Research interests and Collaborators
- Dynamics of cellular signalling networks
- BIOS team (INRA Tours)
- Bursting in self-regulated gene expression model
- Michael Mackey (CAMBAM, McGill University, Canada)
- Marta Tyran-Kamińska (Institute of Mathematics, University of Silesia, Poland)
- Jinzhi Lei (Center for Applied Mathematics, Tsinghua Univeristy, China)
- Changjing Zhuge (Ph.D. student at Center for Applied Mathematics, Tsinghua Univeristy, China)
- Alexandre Ferreira Ramos (Escola de Artes, Ciências e Humanidades, USP, Brazil) )
- Probabilistic differentiation models in the hematopoietic system
- Stochastic nucleation-aggregation model
- Biological polymer model with fragmentation and lengthening under flow
- Individual stochastic spatial/delayed models
- Xavier Pellegrin (Institut Jacques Monod, Université Paris Diderot, France) ).